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Example1
Example2
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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
3 ROCK1 related diseases
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
Summary of query kinase
Query kinase
ROCK1 (
Q13464
)
Kinase group
AGC
Number of conformation types
2
Number of structural templates
6 (
Total 234 inhibitors
)
Number of ROCK1 related diseases
3 (
hsa05130
hsa05131
hsa05132
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
3
3D9VA_H52
(ROCK1)
AGC
H-1152P
I
7
16
24
A
3D9VA_H52
(ROCK1)
AGC
H-1152P
I
7
16
24
7
16
24
A
2ETKA_HFS
(ROCK1)
AGC
HMS2231N23
I
6
12
24
6
12
24
A
2ETRA_Y27
(ROCK1)
AGC
y-27632
I
3
6
3
3
6
3
B
3
2ESMA_M77
(ROCK1)
AGC
HMS2231N23
I
6
15
24
B
2ESMA_M77
(ROCK1)
AGC
HMS2231N23
I
6
15
24
6
15
24
B
2V55A_ANP
(ROCK1)
AGC
Phosphoamino...
I
6
5
19
6
5
19
B
3NCZA_3NC
(ROCK1)
AGC
Cis-4-Amino-...
I
4
41
3
4
41
3