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Example2
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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
2 SYK related diseases
hsa05152
Tuberculosis
hsa05169
Epstein-Barr virus infection
Summary of query kinase
Query kinase
SYK (
P43405
)
Kinase group
TK
Number of conformation types
2
Number of structural templates
6 (
Total 295 inhibitors
)
Number of SYK related diseases
2 (
hsa05152
hsa05169
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
4
1XBCA_STU
(SYK)
TK
staurosporine
I
71
72
105
A
1XBCA_STU
(SYK)
TK
staurosporine
I
71
72
105
71
72
105
A
3FQSA_585
(SYK)
TK
R-406
I
64
28
102
64
28
102
A
1XBBA_STI
(SYK)
TK
Imatinib
I
31
170
75
31
170
75
A
3FQHA_057
(SYK)
TK
Pyrrole Carb...
I
4
8
7
4
8
7
B
2
3FQEA_P5C
(SYK)
TK
AMG_706
I
24
88
63
B
3FQEA_P5C
(SYK)
TK
AMG_706
I
24
88
63
24
88
63
B
3EMGA_685
(SYK)
TK
3emg
I
3
4
10
3
4
10