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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
1 EPHB2 related diseases
603688
Prostate cancer, progression and metastasis of
Summary of query kinase
Query kinase
EPHB2 (
P29323
)
Kinase group
TK
Number of conformation types
0
Number of structural templates
59 (
Total 57 inhibitors
)
Number of EPHB2 related diseases
1 (
603688
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
39
2H8HA_H8H
(SRC)
TK
Saracatinib
I
91
255
126
A
2H8HA_H8H
(SRC)
TK
Saracatinib
I
91
255
126
91
255
126
A
2GQGA_1N1
(ABL1)
TK
Dasatinib
I
74
32
117
74
32
117
A
3K54A_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
3OCTA_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
1XBCA_STU
(SYK)
TK
staurosporine
I
71
72
105
71
72
105
A
2DQ7X_STU
(FYN)
TK
staurosporine
I
91
74
124
91
74
124
A
2HZ4A_4ST
(ABL1)
TK
staurosporine
I
159
103
156
159
103
156
A
3CKXA_STU
(STK24)
TK
staurosporine
I
176
104
141
176
104
141
A
1BYGA_STU
(CSK)
TK
staurosporine
I
85
72
123
85
72
123
A
1QPDA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
1QPJA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
1U59A_STU
(ZAP70)
TK
staurosporine
I
96
80
114
96
80
114
A
3A4OX_STU
(LYN)
TK
staurosporine
I
73
70
88
73
70
88
A
2OFUA_1N9
(LCK)
TK
2-aminopyrim...
I
55
215
101
55
215
101
A
2C0IA_L1G
(HCK)
TK
A-420983
I
61
269
86
61
269
86
A
2C0TA_L3G
(HCK)
TK
A-641359
I
48
260
84
48
260
84
A
1DI9A_MSQ
(MAPK14)
TK
MSQ
I
14
29
29
14
29
29
A
3KF7A_L9G
(MAPK14)
TK
EDD
I
5
18
20
5
18
20
A
1QPEA_PP2
(LCK)
TK
AG 1879
I
29
63
51
29
63
51
A
1OPLA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
1WZYA_F29
(MAPK1)
TK
AC1O4W7N
I
27
48
33
27
48
33
A
2FO0A_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
2F4JA_VX6
(ABL1)
TK
VX-680
I
110
109
134
110
109
134
A
3RHXA_3RH
(FGFR1)
TK
6-o-tolylqui...
I
27
31
67
27
31
67
A
2G2HA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
2XYNA_VX6
(ABL2)
TK
VX-680
I
79
101
105
79
101
105
A
1A9UA_SB2
(MAPK14)
TK
SB 203580
I
21
31
28
21
31
28
A
3L8XA_N4D
(MAPK14)
TK
3cg2
I
91
104
65
91
104
65
A
3RI1A_3RH
(FGFR2)
TK
6-o-tolylqui...
I
29
33
72
29
33
72
A
2HZIA_JIN
(ABL1)
TK
PD180970
I
90
77
120
90
77
120
A
1PMEA_SB2
(MAPK1)
TK
SB 203580
I
16
31
26
16
31
26
A
2ZB1A_GK4
(MAPK14)
TK
biphenyl ami...
II
55
57
54
55
57
54
A
3FQSA_585
(SYK)
TK
R-406
I
64
28
102
64
28
102
A
3OBGA_SB2
(MAPK14)
TK
SB 203580
I
21
31
28
21
31
28
A
3E92A_G6A
(MAPK14)
TK
3e92
I
56
59
55
56
59
55
A
3IKAA_0UN
(EGFR)
TK
2jkk
I
76
120
108
76
120
108
A
3IPHA_G11
(MAPK14)
TK
HMS3303K05
I
57
108
55
57
108
55
A
3PIYA_585
(BTK)
TK
R-406
I
93
17
123
93
17
123
A
1QCFA_PP1
(HCK)
TK
PP1
I
31
65
68
31
65
68
B
20
2ITYA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
B
2ITYA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2ITZA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2ITOA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2VWUA_7X1
(EPHB4)
TK
Chlorobenzod...
I
77
287
111
77
287
111
B
1WVYA_STU
(DAPK1)
TK
staurosporine
I
83
23
55
83
23
55
B
3BKBA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CBLA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CD3A_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
2ITQA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3D7TA_STU
(CSK)
TK
staurosporine
I
70
68
99
70
68
99
B
2ITUA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3LCSA_STU
(ALK)
TK
staurosporine
I
73
100
109
73
100
109
B
2ITWA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3AOXA_EMH
(ALK)
TK
BIRB_796
I
34
28
85
34
28
85
B
3F5PA_741
(IGF1R)
TK
3-cyanoquino...
I
60
123
81
60
123
81
B
3LVPA_PDR
(IGF1R)
TK
DNC009399
I
18
59
52
18
59
52
B
3EKNA_GS3
(INSR)
TK
pyrrolo[2,3-...
I
90
215
127
90
215
127
B
2VX1A_7X8
(EPHB4)
TK
DB07256
I
19
37
15
19
37
15
B
3LW0A_CCX
(IGF1R)
TK
5-vinyl-3-py...
III
53
30
101
53
30
101
B
2XB7A_GUI
(ALK)
TK
NVP-TAE684
I
71
66
107
71
66
107