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Example1
Example2
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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
16 AKT2 related diseases
H00027
Ovarian cancer
H00420
Familial partial lipodystrophy (FPL)
hsa05142
Chagas disease (American trypanosomiasis)
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05162
Measles
hsa05164
Influenza A
hsa05169
Epstein-Barr virus infection
hsa05215
Prostate cancer
hsa05218
Melanoma
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
hsa05222
Small cell lung cancer
125853
Diabetes mellitus, type II
240900
Hypoinsulinemic hypoglycemia with hemihypertrophy
Summary of query kinase
Query kinase
AKT2 (
P31751
)
Kinase group
AGC
Number of conformation types
2
Number of structural templates
11 (
Total 337 inhibitors
)
Number of AKT2 related diseases
16 (
H00027
H00420
hsa05142
hsa05145
hsa05152
hsa05160
hsa05162
hsa05164
...
)
Number of allelic variants
2 (
E17K
R274H
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
8
2JDRA_L20
(AKT2)
AGC
A-443654
I
44
255
61
A
2JDRA_L20
(AKT2)
AGC
A-443654
I
44
255
61
44
255
61
A
3D0EA_G93
(AKT2)
AGC
9-N-ethyl-8-...
I
30
15
45
30
15
45
A
2JDOA_I5S
(AKT2)
AGC
I5S
I
10
22
29
10
22
29
A
3E87A_G95
(AKT2)
AGC
AG_013736
I
9
42
28
9
42
28
A
2XH5A_X37
(AKT2)
AGC
Roscovitine
I
8
28
39
8
28
39
A
2X39A_X39
(AKT2)
AGC
4-Amino-N-(4...
I
6
93
25
6
93
25
A
3E8DA_G98
(AKT2)
AGC
Roscovitine
I
5
19
21
5
19
21
A
3E88A_G96
(AKT2)
AGC
ZSGNCHLJBWLF...
I
3
16
20
3
16
20
B
3
1O6KA_ANP
(AKT2)
AGC
Phosphoamino...
I
11
6
31
B
1O6KA_ANP
(AKT2)
AGC
Phosphoamino...
I
11
6
31
11
6
31
B
1O6LA_ANP
(AKT2)
AGC
Phosphoamino...
I
11
6
31
11
6
31
B
2UW9A_GVP
(AKT2)
AGC
AT7867
I
1
10
15
1
10
15