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Example2
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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
2 ALK related diseases
H00014
Non-small cell lung cancer
613014
{Neuroblastoma, susceptibility to, 3}
Summary of query kinase
Query kinase
ALK (
Q9UM73
)
Kinase group
TK
Number of conformation types
2
Number of structural templates
5 (
Total 242 inhibitors
)
Number of ALK related diseases
2 (
H00014
613014
)
Number of allelic variants
4 (
G1128A
R1192P
R1275Q
T1151M
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
1
2XBAA_571
(ALK)
TK
5-Amido-pyrr...
I
17
55
50
A
2XBAA_571
(ALK)
TK
5-Amido-pyrr...
I
17
55
50
17
55
50
B
4
3LCSA_STU
(ALK)
TK
staurosporine
I
73
100
109
B
3LCSA_STU
(ALK)
TK
staurosporine
I
73
100
109
73
100
109
B
2XB7A_GUI
(ALK)
TK
NVP-TAE684
I
71
66
107
71
66
107
B
3AOXA_EMH
(ALK)
TK
BIRB_796
I
34
28
85
34
28
85
B
3LCTA_ADP
(ALK)
TK
Adenosine-5'...
I
19
12
64
19
12
64