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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
2 BLK related diseases
H00410
Maturity onset diabetes of the young (MODY)
613375
Maturity-onset diabetes of the young, type 11
Summary of query kinase
Query kinase
BLK (
P51451
)
Kinase group
TK
Number of conformation types
0
Number of structural templates
101 (
Total 120 inhibitors
)
Number of BLK related diseases
2 (
H00410
613375
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
69
2IVUA_ZD6
(RET)
TK
Vandetanib
I
83
291
121
A
2IVUA_ZD6
(RET)
TK
Vandetanib
I
83
291
121
83
291
121
A
1QPDA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
2DQ7X_STU
(FYN)
TK
staurosporine
I
91
74
124
91
74
124
A
1QPJA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
2HZ4A_4ST
(ABL1)
TK
staurosporine
I
159
103
156
159
103
156
A
3CKXA_STU
(STK24)
TK
staurosporine
I
176
104
141
176
104
141
A
1SM2A_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1AQ1A_STU
(CDK2)
TK
staurosporine
I
195
76
118
195
76
118
A
1SNUA_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1BYGA_STU
(CSK)
TK
staurosporine
I
85
72
123
85
72
123
A
1NVQA_UCN
(CHEK1)
TK
UCN 02
I
179
65
79
179
65
79
A
1XBCA_STU
(SYK)
TK
staurosporine
I
71
72
105
71
72
105
A
3A4OX_STU
(LYN)
TK
staurosporine
I
73
70
88
73
70
88
A
1NVRA_STU
(CHEK1)
TK
staurosporine
I
179
71
79
179
71
79
A
1XJDA_STU
(PRKCQ)
TK
staurosporine
I
121
101
106
121
101
106
A
1PKDA_UCN
(CDK2)
TK
UCN 02
I
195
67
118
195
67
118
A
1YVJA_4ST
(JAK3)
TK
staurosporine
I
96
90
126
96
90
126
A
2H8HA_H8H
(SRC)
TK
Saracatinib
I
91
255
126
91
255
126
A
2GQGA_1N1
(ABL1)
TK
Dasatinib
I
74
32
117
74
32
117
A
3K54A_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
3OCTA_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
2VTTA_LZD
(CDK2)
TK
pyrazole dia...
I
158
42
111
158
42
111
A
3GENA_B43
(BTK)
TK
7-Cyclopenty...
I
29
110
67
29
110
67
A
2C0IA_L1G
(HCK)
TK
A-420983
I
61
269
86
61
269
86
A
1XBBA_STI
(SYK)
TK
Imatinib
I
31
170
75
31
170
75
A
1Y57A_MPZ
(SRC)
TK
MPZ
I
42
155
94
42
155
94
A
2OFUA_1N9
(LCK)
TK
2-aminopyrim...
I
55
215
101
55
215
101
A
1R78A_FMD
(CDK2)
TK
4-alkynyl ox...
I
127
24
97
127
24
97
A
2F4JA_VX6
(ABL1)
TK
VX-680
I
110
109
134
110
109
134
A
2WIHA_P48
(CDK2)
TK
VX_680
I
111
425
105
111
425
105
A
2IW6A_QQ2
(CDK2)
TK
2iw6
I
112
209
86
112
209
86
A
1M17A_AQ4
(EGFR)
TK
Erlotinib
I
43
166
82
43
166
82
A
2XYNA_VX6
(ABL2)
TK
VX-680
I
79
101
105
79
101
105
A
1OI9A_N20
(CDK2)
TK
NU-6086
I
52
80
61
52
80
61
A
3E5AA_VX6
(AURKA)
TK
VX-680
I
57
107
93
57
107
93
A
3EZRA_EZR
(CDK2)
TK
indazole-ben...
I
30
145
62
30
145
62
A
3FC1X_52P
(MAPK14)
TK
VX-745
I
12
6
21
12
6
21
A
2X81A_ZZL
(AURKA)
TK
MLN8054
I
22
24
64
22
24
64
A
2C0TA_L3G
(HCK)
TK
A-641359
I
48
260
84
48
260
84
A
3HP5A_52P
(MAPK14)
TK
VX-745
I
12
6
21
12
6
21
A
3L8XA_N4D
(MAPK14)
TK
3cg2
I
91
104
65
91
104
65
A
3EOCA_T2A
(CDK2)
TK
5-methyl-7-p...
I
42
148
62
42
148
62
A
3B2WA_9NH
(LCK)
TK
MLS000911569
II
30
32
98
30
32
98
A
3EZVA_EZV
(CDK2)
TK
EZV
I
36
194
65
36
194
65
A
3F5XA_EZV
(CDK2)
TK
EZV
I
36
194
65
36
194
65
A
1NVSA_UCM
(CHEK1)
TK
SB218078
I
97
6
53
97
6
53
A
3PJ3A_04L
(BTK)
TK
Imatinib
II
99
113
134
99
113
134
A
3FQSA_585
(SYK)
TK
R-406
I
64
28
102
64
28
102
A
3HA8A_5JZ
(MAPK14)
TK
DEL-B, 14b
I
59
89
62
59
89
62
A
1OPLA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
3IKAA_0UN
(EGFR)
TK
2jkk
I
76
120
108
76
120
108
A
1YOLA_S03
(SRC)
TK
QGPSFIYTQAON...
I
30
114
75
30
114
75
A
3LZBA_ITI
(EGFR)
TK
Kinome_704
I
13
21
45
13
21
45
A
3BYMA_AM0
(LCK)
TK
triazine 34
I
39
145
100
39
145
100
A
2FO0A_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
3PIYA_585
(BTK)
TK
R-406
I
93
17
123
93
17
123
A
2G2HA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
3EIDA_PO5
(CDK2)
TK
AC1O6YZF
I
63
211
77
63
211
77
A
2BHEA_BRY
(CDK2)
TK
BRY
I
51
31
35
51
31
35
A
2HZIA_JIN
(ABL1)
TK
PD180970
I
90
77
120
90
77
120
A
2ZB1A_GK4
(MAPK14)
TK
biphenyl ami...
II
55
57
54
55
57
54
A
3C4CA_324
(BRAF)
TK
PLX4720
I
35
5
58
35
5
58
A
3EQRA_T74
(TNK2)
TK
T74
I
34
181
86
34
181
86
A
3E92A_G6A
(MAPK14)
TK
3e92
I
56
59
55
56
59
55
A
3C4DA_325
(BRAF)
TK
PLX4720
I
35
5
58
35
5
58
A
3PJ2A_04K
(BTK)
TK
PD166285
I
19
51
70
19
51
70
A
2JEDA_LG8
(PRKCQ)
TK
5-Arylidene-...
I
67
19
87
67
19
87
A
3IPHA_G11
(MAPK14)
TK
HMS3303K05
I
57
108
55
57
108
55
A
3OG7A_032
(BRAF)
TK
PLX4720
I
35
5
58
35
5
58
B
32
2ITOA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
B
2ITOA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2ITYA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2ITZA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
3CD3A_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
2VWUA_7X1
(EPHB4)
TK
Chlorobenzod...
I
77
287
111
77
287
111
B
2ITQA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3D7TA_STU
(CSK)
TK
staurosporine
I
70
68
99
70
68
99
B
2ITUA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3LCSA_STU
(ALK)
TK
staurosporine
I
73
100
109
73
100
109
B
1WVYA_STU
(DAPK1)
TK
staurosporine
I
83
23
55
83
23
55
B
2ITWA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3BKBA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CBLA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3MIYA_B49
(ITK)
TK
Sunitinib
I
70
74
110
70
74
110
B
1H00A_FAP
(CDK2)
TK
AC1NAE4F
I
50
94
75
50
94
75
B
3LW0A_CCX
(IGF1R)
TK
5-vinyl-3-py...
III
53
30
101
53
30
101
B
1H07A_MFP
(CDK2)
TK
AC1NAKJQ
I
90
241
80
90
241
80
B
3AOXA_EMH
(ALK)
TK
BIRB_796
I
34
28
85
34
28
85
B
2C6EA_HPM
(AURKA)
TK
HPM
I
44
237
90
44
237
90
B
2X9FA_X9F
(EPHB4)
TK
X9F
I
46
19
86
46
19
86
B
3EFWA_AK8
(AURKA)
TK
3efw
I
100
59
105
100
59
105
B
2WTWA_ZZL
(AURKA)
TK
MLN8054
I
35
24
70
35
24
70
B
3H10A_97B
(AURKA)
TK
MLN8054
I
39
88
82
39
88
82
B
2J5FA_DJK
(EGFR)
TK
4-anilinoqui...
I
16
212
45
16
212
45
B
3F5PA_741
(IGF1R)
TK
3-cyanoquino...
I
60
123
81
60
123
81
B
2VX1A_7X8
(EPHB4)
TK
DB07256
I
19
37
15
19
37
15
B
3QQUA_01P
(IGF1R)
TK
N~2~-[3-Meth...
I
21
158
73
21
158
73
B
1OIRA_HDY
(CDK2)
TK
AC1O6YZF
I
51
203
64
51
203
64
B
1DI8A_DTQ
(CDK2)
TK
whi-p180
I
26
68
46
26
68
46
B
2XB7A_GUI
(ALK)
TK
NVP-TAE684
I
71
66
107
71
66
107
B
3EKNA_GS3
(INSR)
TK
pyrrolo[2,3-...
I
90
215
127
90
215
127
B
2BMCA_MPY
(AURKA)
TK
PHA-680632
I
107
108
107
107
108
107