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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
16 BRAF related diseases
H00032
Thyroid cancer
H00038
Malignant melanoma
H00523
Noonan syndrome and related disorders
hsa05034
Alcoholism
hsa05160
Hepatitis C
hsa05215
Prostate cancer
hsa05218
Melanoma
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
211980
Adenocarcinoma of lung, somatic
115150
Cardiofaciocutaneous syndrome
OMIM
(164757)
Colorectal cancer, somatic
613707
LEOPARD syndrome 3
OMIM
(164757)
Non-small cell lung cancer, somatic
OMIM
(164757)
Melanoma, malignant, somatic
613706
Noonan syndrome 7
Summary of query kinase
Query kinase
BRAF (
P15056
)
Kinase group
TKL
Number of conformation types
2
Number of structural templates
18 (
Total 508 inhibitors
)
Number of BRAF related diseases
16 (
H00032
H00038
H00523
hsa05034
hsa05160
hsa05215
hsa05218
hsa05220
...
)
Number of allelic variants
25 (
A246P
D594G
D638E
E501G
E501K
G464E
G466V
G469A
G469E
G469R
...
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
13
3C4CA_324
(BRAF)
TKL
PLX4720
I
35
5
58
A
3C4CA_324
(BRAF)
TKL
PLX4720
I
35
5
58
35
5
58
A
3C4DA_325
(BRAF)
TKL
PLX4720
I
35
5
58
35
5
58
A
3OG7A_032
(BRAF)
TKL
PLX4720
I
35
5
58
35
5
58
A
2FB8A_215
(BRAF)
TKL
SB590885
I
7
19
34
7
19
34
A
3PSDA_SM7
(BRAF)
TKL
pyrazole bas...
I
6
27
23
6
27
23
A
3PPKA_FNI
(BRAF)
TKL
3-[(5-Hydrox...
I
5
9
17
5
9
17
A
3PRFA_FP3
(BRAF)
TKL
2-Chloro-5-{...
I
5
8
33
5
8
33
A
3D4QA_SM5
(BRAF)
TKL
pyrazole bas...
I
2
27
16
2
27
16
A
3Q4CA_RSW
(BRAF)
TKL
1,7-Annulate...
I
1
1
14
1
1
14
A
3PSBA_SM6
(BRAF)
TKL
Indenopyrazo...
I
1
2
14
1
2
14
A
3PRIA_FP4
(BRAF)
TKL
Roscovitine
I
1
1
14
1
1
14
A
3PPJA_FOI
(BRAF)
TKL
MLS000077501
I
1
2
14
1
2
14
A
3SKCA_BR2
(BRAF)
TKL
AC1MMMMO
I
1
1
14
1
1
14
E
5
1UWHA_BAX
(BRAF)
TKL
Sorafenib
II
19
39
35
E
1UWHA_BAX
(BRAF)
TKL
Sorafenib
II
19
39
35
19
39
35
E
1UWJA_BAX
(BRAF)
TKL
Sorafenib
II
19
39
35
19
39
35
E
3Q96A_0NF
(BRAF)
TKL
(2s)-N-[3-(2...
II
19
21
35
19
21
35
E
3II5A_831
(BRAF)
TKL
ABT_869
II
7
109
31
7
109
31
E
3IDPA_L1E
(BRAF)
TKL
L1E
II
7
30
24
7
30
24