BioXGEM.
KIDFamMap
Home
Example1
Example2
Statistics
Document
Contact US
Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
1 INSRR related diseases
hsa05215
Prostate cancer
Summary of query kinase
Query kinase
INSRR (
P14616
)
Kinase group
TK
Number of conformation types
0
Number of structural templates
39 (
Total 42 inhibitors
)
Number of INSRR related diseases
1 (
hsa05215
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
18
2HZ4A_4ST
(ABL1)
TK
staurosporine
I
159
103
156
A
2HZ4A_4ST
(ABL1)
TK
staurosporine
I
159
103
156
159
103
156
A
1BYGA_STU
(CSK)
TK
staurosporine
I
85
72
123
85
72
123
A
1QPDA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
1QPJA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
1SM2A_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1SNUA_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1U59A_STU
(ZAP70)
TK
staurosporine
I
96
80
114
96
80
114
A
3CKXA_STU
(STK24)
TK
staurosporine
I
176
104
141
176
104
141
A
2F4JA_VX6
(ABL1)
TK
VX-680
I
110
109
134
110
109
134
A
3PJ3A_04L
(BTK)
TK
Imatinib
II
99
113
134
99
113
134
A
3BPRA_OLP
(MERTK)
TK
compound 52
I
9
10
19
9
10
19
A
2ZYBA_KSL
(LCK)
TK
DB08056
I
36
172
80
36
172
80
A
3IKAA_0UN
(EGFR)
TK
2jkk
I
76
120
108
76
120
108
A
1AGWA_SU2
(FGFR1)
TK
SU 4984
I
77
81
111
77
81
111
A
2RFNA_AM7
(MET)
TK
pyrimidone, 22
I
10
41
22
10
41
22
A
3PIYA_585
(BTK)
TK
R-406
I
93
17
123
93
17
123
A
2H8HA_H8H
(SRC)
TK
Saracatinib
I
91
255
126
91
255
126
A
3EFKA_MT4
(MET)
TK
pyrimidone, 50
I
9
51
22
9
51
22
B
19
3MIYA_B49
(ITK)
TK
Sunitinib
I
70
74
110
B
3MIYA_B49
(ITK)
TK
Sunitinib
I
70
74
110
70
74
110
B
3D7TA_STU
(CSK)
TK
staurosporine
I
70
68
99
70
68
99
B
2ITQA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3LCSA_STU
(ALK)
TK
staurosporine
I
73
100
109
73
100
109
B
2ITUA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
2ITWA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3BKBA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CBLA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CD3A_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
2ITZA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
3EKKA_GS2
(INSR)
TK
pyrrolo[2,3-...
I
33
131
65
33
131
65
B
2VWUA_7X1
(EPHB4)
TK
Chlorobenzod...
I
77
287
111
77
287
111
B
3LW0A_CCX
(IGF1R)
TK
5-vinyl-3-py...
III
53
30
101
53
30
101
B
1YOMA_P01
(SRC)
TK
Lopac0_000938
I
27
95
57
27
95
57
B
3F5PA_741
(IGF1R)
TK
3-cyanoquino...
I
60
123
81
60
123
81
B
2XB7A_GUI
(ALK)
TK
NVP-TAE684
I
71
66
107
71
66
107
B
2ITOA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
3EKNA_GS3
(INSR)
TK
pyrrolo[2,3-...
I
90
215
127
90
215
127
B
2ITYA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
E
2
3C1XA_CKK
(MET)
TK
AZD_1152HQPA
II
19
77
36
E
3C1XA_CKK
(MET)
TK
AZD_1152HQPA
II
19
77
36
19
77
36
E
3LQ8A_88Z
(MET)
TK
AZD_1152HQPA
II
19
71
36
19
71
36