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Example2
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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
13 JAK2 related diseases
H00012
Polycythemia vera
hsa05140
Leishmaniasis
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05162
Measles
hsa05164
Influenza A
hsa05168
Herpes simplex infection
600880
{Budd-Chiari syndrome}
601626
Leukemia, acute myelogenous
254450
Myelofibrosis, idiopathic
OMIM
(147796)
Myeloproliferative disorder with erythrocytosis
263300
Polycythemia vera
614521
Thrombocythemia 3
Summary of query kinase
Query kinase
JAK2 (
O60674
)
Kinase group
TK
Number of conformation types
2
Number of structural templates
14 (
Total 612 inhibitors
)
Number of JAK2 related diseases
13 (
H00012
hsa05140
hsa05145
hsa05152
hsa05162
hsa05164
hsa05168
600880
...
)
Number of allelic variants
4 (
K539L
K607N
V617F
V617I
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
1
3JY9A_JZH
(JAK2)
TK
atropisomer 1
I
11
13
32
A
3JY9A_JZH
(JAK2)
TK
atropisomer 1
I
11
13
32
11
13
32
B
13
2B7AA_IZA
(JAK2)
TK
Pyridone 6
I
34
12
65
B
2B7AA_IZA
(JAK2)
TK
Pyridone 6
I
34
12
65
34
12
65
B
3IO7A_1P5
(JAK2)
TK
CP_690550
I
24
65
60
24
65
60
B
3IOKA_1P6
(JAK2)
TK
PTK_787
I
16
98
47
16
98
47
B
3FUPA_MI1
(JAK2)
TK
CP690550
I
16
27
32
16
27
32
B
2XA4A_AZ5
(JAK2)
TK
AZD1480, AZ...
I
15
85
58
15
85
58
B
3E63A_5B2
(JAK2)
TK
5-phenyl-1H-...
I
15
29
39
15
29
39
B
3KCKA_3KC
(JAK2)
TK
L-779450
I
13
20
44
13
20
44
B
3KRRA_DQX
(JAK2)
TK
DQX
I
8
15
48
8
15
48
B
2W1IA_L0I
(JAK2)
TK
AT9283
I
7
13
21
7
13
21
B
3LPBA_NVB
(JAK2)
TK
Anilinopyraz...
I
6
8
19
6
8
19
B
3Q32A_J2I
(JAK2)
TK
2-(2,6-Diflu...
I
4
29
18
4
29
18
B
3E64A_5B3
(JAK2)
TK
3e64
I
3
10
20
3
10
20
B
3E62A_5B1
(JAK2)
TK
5-bromo-1H-i...
I
1
1
12
1
1
12