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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
1 TEC related diseases
OMIM
(600583)
Transient erythroblastopenia of childhood
Summary of query kinase
Query kinase
TEC (
P42680
)
Kinase group
TK
Number of conformation types
0
Number of structural templates
49 (
Total 28 inhibitors
)
Number of TEC related diseases
1 (
OMIM:600583
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
29
2IVUA_ZD6
(RET)
TK
Vandetanib
I
83
291
121
A
2IVUA_ZD6
(RET)
TK
Vandetanib
I
83
291
121
83
291
121
A
2GQGA_1N1
(ABL1)
TK
Dasatinib
I
74
32
117
74
32
117
A
3K54A_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
3OCTA_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
1SM2A_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
2HZ4A_4ST
(ABL1)
TK
staurosporine
I
159
103
156
159
103
156
A
1SNUA_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1U59A_STU
(ZAP70)
TK
staurosporine
I
96
80
114
96
80
114
A
1XBCA_STU
(SYK)
TK
staurosporine
I
71
72
105
71
72
105
A
1XJDA_STU
(PRKCQ)
TK
staurosporine
I
121
101
106
121
101
106
A
1YVJA_4ST
(JAK3)
TK
staurosporine
I
96
90
126
96
90
126
A
1QPDA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
2DQ7X_STU
(FYN)
TK
staurosporine
I
91
74
124
91
74
124
A
3CKXA_STU
(STK24)
TK
staurosporine
I
176
104
141
176
104
141
A
1QPJA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
2HY81_1ST
(PAK1)
TK
UCN 02
I
58
20
75
58
20
75
A
3EQFA_KSA
(MAP2K1)
TK
k-252a
I
42
51
57
42
51
57
A
3GENA_B43
(BTK)
TK
7-Cyclopenty...
I
29
110
67
29
110
67
A
2H8HA_H8H
(SRC)
TK
Saracatinib
I
91
255
126
91
255
126
A
2G2HA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
2XYNA_VX6
(ABL2)
TK
VX-680
I
79
101
105
79
101
105
A
2HZIA_JIN
(ABL1)
TK
PD180970
I
90
77
120
90
77
120
A
3FQSA_585
(SYK)
TK
R-406
I
64
28
102
64
28
102
A
3BYMA_AM0
(LCK)
TK
triazine 34
I
39
145
100
39
145
100
A
3IKAA_0UN
(EGFR)
TK
2jkk
I
76
120
108
76
120
108
A
3PIYA_585
(BTK)
TK
R-406
I
93
17
123
93
17
123
A
1OPLA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
2FO0A_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
2F4JA_VX6
(ABL1)
TK
VX-680
I
110
109
134
110
109
134
B
20
2ITZA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
B
2ITZA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2ITOA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2ITYA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
3D7TA_STU
(CSK)
TK
staurosporine
I
70
68
99
70
68
99
B
3LCSA_STU
(ALK)
TK
staurosporine
I
73
100
109
73
100
109
B
2ITQA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
2ITUA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
2WTWA_ZZL
(AURKA)
TK
MLN8054
I
35
24
70
35
24
70
B
2ITWA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3H10A_97B
(AURKA)
TK
MLN8054
I
39
88
82
39
88
82
B
1OKYA_STU
(PDPK1)
TK
staurosporine
I
179
67
109
179
67
109
B
3BKBA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CBLA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
1OKZA_UCN
(PDPK1)
TK
UCN 02
I
179
60
109
179
60
109
B
3CD3A_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
2VWUA_7X1
(EPHB4)
TK
Chlorobenzod...
I
77
287
111
77
287
111
B
3F5PA_741
(IGF1R)
TK
3-cyanoquino...
I
60
123
81
60
123
81
B
3LW0A_CCX
(IGF1R)
TK
5-vinyl-3-py...
III
53
30
101
53
30
101
B
2XB7A_GUI
(ALK)
TK
NVP-TAE684
I
71
66
107
71
66
107
B
3EKNA_GS3
(INSR)
TK
pyrrolo[2,3-...
I
90
215
127
90
215
127