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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
4 BTK related diseases
H00085
Agammaglobulinemias
H00254
Pituitary Dwarfism (PD)
300755
Agammaglobulinemia, X-linked 1
307200
Agammaglobulinemia and isolated hormone deficiency
Summary of query kinase
Query kinase
BTK (
Q06187
)
Kinase group
TK
Number of conformation types
1
Number of structural templates
10 (
Total 93 inhibitors
)
Number of BTK related diseases
4 (
H00085
H00254
300755
307200
)
Number of allelic variants
35 (
A-D
A607D
C502X
C506R
E240X
E589G
E636X
G613D
K430E
L408P
...
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
10
3PJ3A_04L
(BTK)
TK
Imatinib
II
99
113
134
A
3PJ3A_04L
(BTK)
TK
Imatinib
II
99
113
134
99
113
134
A
3PIYA_585
(BTK)
TK
R-406
I
93
17
123
93
17
123
A
3OCTA_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
3K54A_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
3PJ1A_LHL
(BTK)
TK
AZD_1152HQPA
I
30
99
96
30
99
96
A
3GENA_B43
(BTK)
TK
7-Cyclopenty...
I
29
110
67
29
110
67
A
3OCSA_746
(BTK)
TK
CGI1746, 2
I
25
89
76
25
89
76
A
3PJ2A_04K
(BTK)
TK
PD166285
I
19
51
70
19
51
70
A
3PIXA_027
(BTK)
TK
7-(4-Methylp...
I
15
33
55
15
33
55
A
3PIZA_03C
(BTK)
TK
JNJ_28312141
I
2
2
6
2
2
6