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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
Summary of query kinase
Query kinase
FRK (
P42685
)
Kinase group
TK
Number of conformation types
0
Number of structural templates
51 (
Total 109 inhibitors
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
43
1AQ1A_STU
(CDK2)
TK
staurosporine
I
195
76
118
A
1AQ1A_STU
(CDK2)
TK
staurosporine
I
195
76
118
195
76
118
A
2DQ7X_STU
(FYN)
TK
staurosporine
I
91
74
124
91
74
124
A
1NVQA_UCN
(CHEK1)
TK
UCN 02
I
179
65
79
179
65
79
A
2HZ4A_4ST
(ABL1)
TK
staurosporine
I
159
103
156
159
103
156
A
1NVRA_STU
(CHEK1)
TK
staurosporine
I
179
71
79
179
71
79
A
3A4OX_STU
(LYN)
TK
staurosporine
I
73
70
88
73
70
88
A
1PKDA_UCN
(CDK2)
TK
UCN 02
I
195
67
118
195
67
118
A
1QPDA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
1QPJA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
1U59A_STU
(ZAP70)
TK
staurosporine
I
96
80
114
96
80
114
A
1XBCA_STU
(SYK)
TK
staurosporine
I
71
72
105
71
72
105
A
2H8HA_H8H
(SRC)
TK
Saracatinib
I
91
255
126
91
255
126
A
2GQGA_1N1
(ABL1)
TK
Dasatinib
I
74
32
117
74
32
117
A
3K54A_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
3OCTA_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
1XBBA_STI
(SYK)
TK
Imatinib
I
31
170
75
31
170
75
A
1Y57A_MPZ
(SRC)
TK
MPZ
I
42
155
94
42
155
94
A
2VTTA_LZD
(CDK2)
TK
pyrazole dia...
I
158
42
111
158
42
111
A
2C0TA_L3G
(HCK)
TK
A-641359
I
48
260
84
48
260
84
A
2OFUA_1N9
(LCK)
TK
2-aminopyrim...
I
55
215
101
55
215
101
A
2F4JA_VX6
(ABL1)
TK
VX-680
I
110
109
134
110
109
134
A
2WIHA_P48
(CDK2)
TK
VX_680
I
111
425
105
111
425
105
A
1M17A_AQ4
(EGFR)
TK
Erlotinib
I
43
166
82
43
166
82
A
2XYNA_VX6
(ABL2)
TK
VX-680
I
79
101
105
79
101
105
A
1OI9A_N20
(CDK2)
TK
NU-6086
I
52
80
61
52
80
61
A
2IW6A_QQ2
(CDK2)
TK
2iw6
I
112
209
86
112
209
86
A
2C0IA_L1G
(HCK)
TK
A-420983
I
61
269
86
61
269
86
A
3C4CA_324
(BRAF)
TK
PLX4720
I
35
5
58
35
5
58
A
3C4DA_325
(BRAF)
TK
PLX4720
I
35
5
58
35
5
58
A
3OG7A_032
(BRAF)
TK
PLX4720
I
35
5
58
35
5
58
A
3GENA_B43
(BTK)
TK
7-Cyclopenty...
I
29
110
67
29
110
67
A
3IKAA_0UN
(EGFR)
TK
2jkk
I
76
120
108
76
120
108
A
2BHEA_BRY
(CDK2)
TK
BRY
I
51
31
35
51
31
35
A
3PIYA_585
(BTK)
TK
R-406
I
93
17
123
93
17
123
A
3PJ3A_04L
(BTK)
TK
Imatinib
II
99
113
134
99
113
134
A
1R78A_FMD
(CDK2)
TK
4-alkynyl ox...
I
127
24
97
127
24
97
A
1OPLA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
2FO0A_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
2G2HA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
1AGWA_SU2
(FGFR1)
TK
SU 4984
I
77
81
111
77
81
111
A
2HZIA_JIN
(ABL1)
TK
PD180970
I
90
77
120
90
77
120
A
2X7OA_ZOP
(TGFBR1)
TK
Imatinib
I
18
43
35
18
43
35
A
3FQSA_585
(SYK)
TK
R-406
I
64
28
102
64
28
102
B
4
3D7TA_STU
(CSK)
TK
staurosporine
I
70
68
99
B
3D7TA_STU
(CSK)
TK
staurosporine
I
70
68
99
70
68
99
B
2VWUA_7X1
(EPHB4)
TK
Chlorobenzod...
I
77
287
111
77
287
111
B
2X9FA_X9F
(EPHB4)
TK
X9F
I
46
19
86
46
19
86
B
3KCKA_3KC
(JAK2)
TK
L-779450
I
13
20
44
13
20
44
E
3
1T46A_STI
(KIT)
TK
Imatinib
II
22
176
56
E
1T46A_STI
(KIT)
TK
Imatinib
II
22
176
56
22
176
56
E
3G0EA_B49
(KIT)
TK
Sunitinib
I
37
40
78
37
40
78
E
3G0FA_B49
(KIT)
TK
Sunitinib
I
37
40
78
37
40
78
F
1
2PL0A_STI
(LCK)
TK
Imatinib
II
12
142
33
F
2PL0A_STI
(LCK)
TK
Imatinib
II
12
142
33
12
142
33