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Example2
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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
1 PLK3 related diseases
hsa05152
Tuberculosis
Summary of query kinase
Query kinase
PLK3 (
Q9H4B4
)
Kinase group
Other
Number of conformation types
0
Number of structural templates
84 (
Total 109 inhibitors
)
Number of PLK3 related diseases
1 (
hsa05152
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
62
3KB7A_071
(PLK1)
Other
MLN_518
I
39
176
54
A
3KB7A_071
(PLK1)
Other
MLN_518
I
39
176
54
39
176
54
A
2XNMA_WGZ
(NEK2)
Other
benzimidazol...
I
12
93
9
12
93
9
A
2XNOA_ED8
(NEK2)
Other
5-{6-[(1-Met...
I
12
82
9
12
82
9
A
2WIHA_P48
(CDK2)
Other
VX_680
I
111
425
105
111
425
105
A
2XNNA_430
(NEK2)
Other
Kinome_3463
I
12
83
9
12
83
9
A
2I40A_BLZ
(CDK2)
Other
2i40
I
34
95
16
34
95
16
A
2YACA_937
(PLK1)
Other
1-(2-Hydroxy...
I
7
59
11
7
59
11
A
2WIPA_P49
(CDK2)
Other
DB08355
I
14
101
37
14
101
37
A
3MVLA_38P
(MAPK14)
Other
38P
I
50
308
44
50
308
44
A
3FC2A_IBI
(PLK1)
Other
BI 2536
I
38
72
42
38
72
42
A
2RKUA_R78
(PLK1)
Other
BI 2536
I
37
59
35
37
59
35
A
2HZ4A_4ST
(ABL1)
Other
staurosporine
I
159
103
156
159
103
156
A
3CKXA_STU
(STK24)
Other
staurosporine
I
176
104
141
176
104
141
A
1PKDA_UCN
(CDK2)
Other
UCN 02
I
195
67
118
195
67
118
A
1Q3DA_STU
(GSK3B)
Other
staurosporine
I
115
71
61
115
71
61
A
1AQ1A_STU
(CDK2)
Other
staurosporine
I
195
76
118
195
76
118
A
1QPDA_STU
(LCK)
Other
staurosporine
I
115
76
126
115
76
126
A
1NVQA_UCN
(CHEK1)
Other
UCN 02
I
179
65
79
179
65
79
A
1QPJA_STU
(LCK)
Other
staurosporine
I
115
76
126
115
76
126
A
2C0IA_L1G
(HCK)
Other
A-420983
I
61
269
86
61
269
86
A
1NVRA_STU
(CHEK1)
Other
staurosporine
I
179
71
79
179
71
79
A
1XJDA_STU
(PRKCQ)
Other
staurosporine
I
121
101
106
121
101
106
A
1NXKA_STU
(MAPKAPK2)
Other
staurosporine
I
110
67
51
110
67
51
A
1YHSA_STU
(PIM1)
Other
staurosporine
I
78
64
50
78
64
50
A
2XNPA_WCX
(NEK2)
Other
4-{5-[(1-Met...
I
12
34
17
12
34
17
A
2EUFB_LQQ
(CDK6)
Other
Pyrido-[2,3-...
I
13
122
50
13
122
50
A
2C0OA_L2G
(HCK)
Other
A-770041
I
41
222
65
41
222
65
A
2C0TA_L3G
(HCK)
Other
A-641359
I
48
260
84
48
260
84
A
3MVMA_39P
(MAPK14)
Other
39P
I
24
247
38
24
247
38
A
3I4BA_Z48
(GSK3B)
Other
Z48
I
18
77
34
18
77
34
A
3I5ZA_Z48
(MAPK1)
Other
Z48
I
12
64
26
12
64
26
A
2ETMA_7PY
(PTK2)
Other
DB07248
I
10
101
25
10
101
25
A
2FGIA_PD1
(FGFR1)
Other
Pyrido[2,3-d...
I
24
157
70
24
157
70
A
2W17A_I19
(CDK2)
Other
DB07936
I
25
134
47
25
134
47
A
2J51A_DKI
(SLK)
Other
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
2JFLA_DKI
(SLK)
Other
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
3EOCA_T2A
(CDK2)
Other
5-methyl-7-p...
I
42
148
62
42
148
62
A
2VV9A_IM9
(CDK2)
Other
2vv9
I
19
61
36
19
61
36
A
3BV2A_P38
(MAPK14)
Other
MLN_518
II
20
142
37
20
142
37
A
1YI3A_LY2
(PIM1)
Other
LY294002
I
3
2
2
3
2
2
A
1OPLA_P16
(ABL1)
Other
PD166326
I
89
70
123
89
70
123
A
2GHGA_A53
(CHEK1)
Other
oxindole pyr...
I
10
102
25
10
102
25
A
3M2WA_L8I
(MAPKAPK2)
Other
Sunitinib
I
84
90
47
84
90
47
A
2FO0A_P16
(ABL1)
Other
PD166326
I
89
70
123
89
70
123
A
2E9VA_85A
(CHEK1)
Other
macrocyclic ...
I
14
121
27
14
121
27
A
2B55A_D31
(CDK2)
Other
D31
I
27
87
53
27
87
53
A
3DOGA_NNN
(CDK2)
Other
NSC743927
I
50
239
48
50
239
48
A
2G2HA_P16
(ABL1)
Other
PD166326
I
89
70
123
89
70
123
A
1OI9A_N20
(CDK2)
Other
NU-6086
I
52
80
61
52
80
61
A
2F4JA_VX6
(ABL1)
Other
VX-680
I
110
109
134
110
109
134
A
3OT8A_MI5
(CHEK1)
Other
VX_680
I
14
63
25
14
63
25
A
2HZIA_JIN
(ABL1)
Other
PD180970
I
90
77
120
90
77
120
A
3DT1A_P40
(MAPK14)
Other
DB08351
II
18
69
32
18
69
32
A
3BYMA_AM0
(LCK)
Other
triazine 34
I
39
145
100
39
145
100
A
2OFUA_1N9
(LCK)
Other
2-aminopyrim...
I
55
215
101
55
215
101
A
2BRMA_DFZ
(CHEK1)
Other
DFZ
I
21
88
36
21
88
36
A
1BL6A_SB6
(MAPK14)
Other
sb216995
I
46
110
50
46
110
50
A
2BRNA_DF1
(CHEK1)
Other
pyrrolopyrim...
I
30
119
42
30
119
42
A
1ZZLA_TZY
(MAPK14)
Other
CP-808844
I
36
84
44
36
84
44
A
3E5AA_VX6
(AURKA)
Other
VX-680
I
57
107
93
57
107
93
A
2BROA_DF2
(CHEK1)
Other
pyrrolopyrim...
I
29
109
40
29
109
40
A
2J90A_IZA
(DAPK3)
Other
Pyridone 6
I
40
50
42
40
50
42
B
22
2XCKA_MH4
(PDPK1)
Other
MH4
I
46
431
75
B
2XCKA_MH4
(PDPK1)
Other
MH4
I
46
431
75
46
431
75
B
2XCHA_CKG
(PDPK1)
Other
LY_333531
I
19
83
41
19
83
41
B
1OKYA_STU
(PDPK1)
Other
staurosporine
I
179
67
109
179
67
109
B
1OKZA_UCN
(PDPK1)
Other
UCN 02
I
179
60
109
179
60
109
B
1GIJA_2PU
(CDK2)
Other
pyrazole-3-y...
I
19
113
34
19
113
34
B
2C6EA_HPM
(AURKA)
Other
HPM
I
44
237
90
44
237
90
B
3AMAA_SKE
(PRKACA)
Other
JNJ-7706621
I
46
26
35
46
26
35
B
3QD0A_3Q4
(PDPK1)
Other
(3s,6r)-1-[2...
I
28
114
63
28
114
63
B
1CKPA_PVB
(CDK2)
Other
Purvalanol B
I
35
76
36
35
76
36
B
2F2CB_AP9
(CDK6)
Other
MLS000911551
I
24
147
39
24
147
39
B
3NAYA_MP6
(PDPK1)
Other
ZINC13474643
I
20
81
37
20
81
37
B
1UNLA_RRC
(CDK5)
Other
roscovitine
I
45
237
47
45
237
47
B
3DDQA_RRC
(CDK2)
Other
roscovitine
I
50
240
50
50
240
50
B
3NRMA_NRM
(AURKA)
Other
CAS404828_08_6
I
32
33
60
32
33
60
B
1W0XC_OLO
(CDK2)
Other
olomoucine
I
43
195
47
43
195
47
B
2A0CX_CK9
(CDK2)
Other
purine deriv...
I
45
226
50
45
226
50
B
3NS9A_NS9
(CDK2)
Other
pyrazolo[1,5...
I
44
196
47
44
196
47
B
2A4LA_RRC
(CDK2)
Other
roscovitine
I
50
240
50
50
240
50
B
3PJ8A_404
(CDK2)
Other
imidazo[2,1-...
I
47
223
49
47
223
49
B
2XRUA_400
(AURKA)
Other
VX_680
I
33
152
63
33
152
63
B
3HA6A_2JZ
(AURKA)
Other
DEL-A, 10
I
10
35
30
10
35
30
B
3EFWA_AK8
(AURKA)
Other
3efw
I
100
59
105
100
59
105