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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
5 CDK2 related diseases
hsa05162
Measles
hsa05168
Herpes simplex infection
hsa05169
Epstein-Barr virus infection
hsa05215
Prostate cancer
hsa05222
Small cell lung cancer
Summary of query kinase
Query kinase
CDK2 (
P24941
)
Kinase group
CMGC
Number of conformation types
3
Number of structural templates
186 (
Total 2040 inhibitors
)
Number of CDK2 related diseases
5 (
hsa05162
hsa05168
hsa05169
hsa05215
hsa05222
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
76
1AQ1A_STU
(CDK2)
CMGC
staurosporine
I
195
76
118
A
1AQ1A_STU
(CDK2)
CMGC
staurosporine
I
195
76
118
195
76
118
A
1PKDA_UCN
(CDK2)
CMGC
UCN 02
I
195
67
118
195
67
118
A
2VTTA_LZD
(CDK2)
CMGC
pyrazole dia...
I
158
42
111
158
42
111
A
1R78A_FMD
(CDK2)
CMGC
4-alkynyl ox...
I
127
24
97
127
24
97
A
2IW6A_QQ2
(CDK2)
CMGC
2iw6
I
112
209
86
112
209
86
A
2WIHA_P48
(CDK2)
CMGC
VX_680
I
111
425
105
111
425
105
A
3EIDA_PO5
(CDK2)
CMGC
AC1O6YZF
I
63
211
77
63
211
77
A
1OI9A_N20
(CDK2)
CMGC
NU-6086
I
52
80
61
52
80
61
A
2BHEA_BRY
(CDK2)
CMGC
BRY
I
51
31
35
51
31
35
A
3DOGA_NNN
(CDK2)
CMGC
NSC743927
I
50
239
48
50
239
48
A
2R3NA_SCZ
(CDK2)
CMGC
AC1LZZHM
I
46
175
57
46
175
57
A
3EJ1A_5BP
(CDK2)
CMGC
AC1OCFRV
I
46
92
62
46
92
62
A
1G5SA_I17
(CDK2)
CMGC
H724
I
43
170
58
43
170
58
A
3EOCA_T2A
(CDK2)
CMGC
5-methyl-7-p...
I
42
148
62
42
148
62
A
3DDPA_RC8
(CDK2)
CMGC
Roscovitine
I
42
133
57
42
133
57
A
2VTQA_LZA
(CDK2)
CMGC
pyrazole dia...
I
36
25
31
36
25
31
A
3F5XA_EZV
(CDK2)
CMGC
EZV
I
36
194
65
36
194
65
A
3EZVA_EZV
(CDK2)
CMGC
EZV
I
36
194
65
36
194
65
A
2VU3A_LZE
(CDK2)
CMGC
AT7519
I
35
22
29
35
22
29
A
1FINA_ATP
(CDK2)
CMGC
Adenosine-5'...
I
34
13
66
34
13
66
A
1FQ1B_ATP
(CDK2)
CMGC
Adenosine-5'...
I
34
13
66
34
13
66
A
1QMZA_ATP
(CDK2)
CMGC
Adenosine-5'...
I
34
13
66
34
13
66
A
2CJMA_ATP
(CDK2)
CMGC
Adenosine-5'...
I
34
13
66
34
13
66
A
2I40A_BLZ
(CDK2)
CMGC
2i40
I
34
95
16
34
95
16
A
2CCHA_ATP
(CDK2)
CMGC
Adenosine-5'...
I
34
13
66
34
13
66
A
1GY3A_ATP
(CDK2)
CMGC
Adenosine-5'...
I
34
13
66
34
13
66
A
1JSTA_ATP
(CDK2)
CMGC
Adenosine-5'...
I
34
13
66
34
13
66
A
1OIYA_N41
(CDK2)
CMGC
N41
I
33
49
34
33
49
34
A
1OGUA_ST8
(CDK2)
CMGC
ST8
I
31
21
34
31
21
34
A
2IW9A_4SP
(CDK2)
CMGC
nu6102
I
30
33
30
30
33
30
A
3EZRA_EZR
(CDK2)
CMGC
indazole-ben...
I
30
145
62
30
145
62
A
2IW8A_4SP
(CDK2)
CMGC
nu6102
I
30
33
30
30
33
30
A
1H1SA_4SP
(CDK2)
CMGC
nu6102
I
30
33
30
30
33
30
A
2B55A_D31
(CDK2)
CMGC
D31
I
27
87
53
27
87
53
A
2W17A_I19
(CDK2)
CMGC
DB07936
I
25
134
47
25
134
47
A
1VYWA_292
(CDK2)
CMGC
PNU-292137 I...
I
20
91
38
20
91
38
A
2VV9A_IM9
(CDK2)
CMGC
2vv9
I
19
61
36
19
61
36
A
2C5NA_CK8
(CDK2)
CMGC
CK8
I
14
49
26
14
49
26
A
2WIPA_P49
(CDK2)
CMGC
DB08355
I
14
101
37
14
101
37
A
1GIHA_1PU
(CDK2)
CMGC
1PU
I
13
60
35
13
60
35
A
3BHUA_MHR
(CDK2)
CMGC
Benzo[c][2,7...
I
11
13
27
11
13
27
A
1H1QA_2A6
(CDK2)
CMGC
NU-6094
I
10
50
25
10
50
25
A
2UUEA_MTZ
(CDK2)
CMGC
Kinome_636
I
10
5
16
10
5
16
A
1PYEA_PM1
(CDK2)
CMGC
AC1NRCTO
I
10
54
35
10
54
35
A
2C5VA_CK4
(CDK2)
CMGC
4-(2,4-DIMET...
I
10
22
18
10
22
18
A
3BHTA_MFR
(CDK2)
CMGC
Meridianin A
I
9
11
26
9
11
26
A
2WEVA_CK7
(CDK2)
CMGC
CK7
I
8
23
17
8
23
17
A
2C6TA_DT5
(CDK2)
CMGC
2c6m
I
8
40
39
8
40
39
A
2VTNA_LZ7
(CDK2)
CMGC
pyrazole ami...
I
8
48
24
8
48
24
A
2C5OA_CK2
(CDK2)
CMGC
CK2
I
7
6
14
7
6
14
A
2WXVA_WXV
(CDK2)
CMGC
JNJ_28312141
I
7
24
23
7
24
23
A
2W05A_FRT
(CDK2)
CMGC
2w05
I
7
51
14
7
51
14
A
2WPAA_889
(CDK2)
CMGC
JNJ_28312141
I
6
10
28
6
10
28
A
3BHVA_VAR
(CDK2)
CMGC
Meridianin A
I
5
8
16
5
8
16
A
1P2AA_5BN
(CDK2)
CMGC
5BN
I
4
23
16
4
23
16
A
1OIUA_N76
(CDK2)
CMGC
N76
I
4
25
16
4
25
16
A
2UZEA_C95
(CDK2)
CMGC
STK004775
I
4
9
6
4
9
6
A
3MY5A_RFZ
(CDK2)
CMGC
5,6-Dichloro...
I
4
8
5
4
8
5
A
2BKZA_SBC
(CDK2)
CMGC
SBC
I
3
22
21
3
22
21
A
1FVVA_107
(CDK2)
CMGC
GW-8510
I
2
2
5
2
2
5
A
2BPMA_529
(CDK2)
CMGC
MLS000561975
I
2
2
17
2
2
17
A
2G9XA_NU5
(CDK2)
CMGC
O6-Cyclohexy...
I
2
7
10
2
7
10
A
1P5EA_TBS
(CDK2)
CMGC
4,5,6,7-tetr...
I
2
6
5
2
6
5
A
2UZBA_C75
(CDK2)
CMGC
2uzb
I
2
14
5
2
14
5
A
2B52A_D42
(CDK2)
CMGC
D42
I
2
32
10
2
32
10
A
2C5XA_MTW
(CDK2)
CMGC
2c5x
I
1
1
5
1
1
5
A
2C4GA_514
(CDK2)
CMGC
AH-262/33700...
I
1
1
5
1
1
5
A
2BTSA_U32
(CDK2)
CMGC
MLS000100704
I
1
1
5
1
1
5
A
1DM2A_HMD
(CDK2)
CMGC
N-[(1-adaman...
I
1
1
5
1
1
5
A
2BHHA_RYU
(CDK2)
CMGC
CAS854171_35_0
I
1
15
5
1
15
5
A
1E9HA_INR
(CDK2)
CMGC
MLS000703279
I
1
2
5
1
2
5
A
2UZLA_C94
(CDK2)
CMGC
2uzl
I
1
12
5
1
12
5
A
2UZDA_C85
(CDK2)
CMGC
2uzd
I
1
13
5
1
13
5
A
2X1NA_X1N
(CDK2)
CMGC
AC1O6ZF0
I
1
1
5
1
1
5
A
1H1PA_CMG
(CDK2)
CMGC
O6-Substitut...
I
1
15
5
1
15
5
A
2J9MA_PY8
(CDK2)
CMGC
pyrrolopyrim...
I
1
1
5
1
1
5
B
107
1H07A_MFP
(CDK2)
CMGC
AC1NAKJQ
I
90
241
80
B
1H07A_MFP
(CDK2)
CMGC
AC1NAKJQ
I
90
241
80
90
241
80
B
1OIRA_HDY
(CDK2)
CMGC
AC1O6YZF
I
51
203
64
51
203
64
B
1H00A_FAP
(CDK2)
CMGC
AC1NAE4F
I
50
94
75
50
94
75
B
3DDQA_RRC
(CDK2)
CMGC
roscovitine
I
50
240
50
50
240
50
B
2A4LA_RRC
(CDK2)
CMGC
roscovitine
I
50
240
50
50
240
50
B
3PJ8A_404
(CDK2)
CMGC
imidazo[2,1-...
I
47
223
49
47
223
49
B
2A0CX_CK9
(CDK2)
CMGC
purine deriv...
I
45
226
50
45
226
50
B
3NS9A_NS9
(CDK2)
CMGC
pyrazolo[1,5...
I
44
196
47
44
196
47
B
1W0XC_OLO
(CDK2)
CMGC
olomoucine
I
43
195
47
43
195
47
B
2FVDA_LIA
(CDK2)
CMGC
[4-Amino-2-[...
I
39
16
29
39
16
29
B
1HCKA_ATP
(CDK2)
CMGC
Adenosine-5'...
I
38
13
63
38
13
63
B
2CCIA_ATP
(CDK2)
CMGC
Adenosine-5'...
I
38
13
63
38
13
63
B
1B39A_ATP
(CDK2)
CMGC
Adenosine-5'...
I
38
13
63
38
13
63
B
1B38A_ATP
(CDK2)
CMGC
Adenosine-5'...
I
38
13
63
38
13
63
B
1CKPA_PVB
(CDK2)
CMGC
Purvalanol B
I
35
76
36
35
76
36
B
2R3GA_SC9
(CDK2)
CMGC
2r3j
I
30
137
50
30
137
50
B
2R3KA_SCQ
(CDK2)
CMGC
2r3j
I
28
95
49
28
95
49
B
2VTSA_LZC
(CDK2)
CMGC
DB08140
I
28
54
26
28
54
26
B
2C6IA_DT1
(CDK2)
CMGC
2c6i
I
27
41
48
27
41
48
B
2R3JA_SCJ
(CDK2)
CMGC
2r3j
I
27
99
49
27
99
49
B
1DI8A_DTQ
(CDK2)
CMGC
whi-p180
I
26
68
46
26
68
46
B
3PY0A_SU9
(CDK2)
CMGC
SU 9516
I
25
19
33
25
19
33
B
3PY1A_SU9
(CDK2)
CMGC
SU 9516
I
25
19
33
25
19
33
B
1PF8A_SU9
(CDK2)
CMGC
SU 9516
I
25
19
33
25
19
33
B
2C68A_CT6
(CDK2)
CMGC
2c68
I
23
73
43
23
73
43
B
2C6OA_4SP
(CDK2)
CMGC
nu6102
I
23
33
27
23
33
27
B
2R3IA_SCF
(CDK2)
CMGC
2c68
I
23
89
43
23
89
43
B
2R3FA_SC8
(CDK2)
CMGC
2c68
I
22
62
43
22
62
43
B
2C69A_CT8
(CDK2)
CMGC
CT8
I
22
62
38
22
62
38
B
2W1HA_L0H
(CDK2)
CMGC
DB08066
I
20
43
42
20
43
42
B
1GIJA_2PU
(CDK2)
CMGC
pyrazole-3-y...
I
19
113
34
19
113
34
B
2R3LA_SCW
(CDK2)
CMGC
2r3j
I
19
63
41
19
63
41
B
2R3OA_2SC
(CDK2)
CMGC
4-(Benzylami...
I
18
36
43
18
36
43
B
1JVPP_LIG
(CDK2)
CMGC
ellipticine
I
17
30
45
17
30
45
B
2R3HA_SCE
(CDK2)
CMGC
benzimidazoq...
I
15
40
39
15
40
39
B
3LFSA_A07
(CDK2)
CMGC
DNC010588
I
14
111
31
14
111
31
B
1PXPA_CK8
(CDK2)
CMGC
CK8
I
14
49
26
14
49
26
B
3LFNA_A27
(CDK2)
CMGC
DNC010577
I
14
98
33
14
98
33
B
1OIQA_HDU
(CDK2)
CMGC
AC1L9L2U
I
14
56
31
14
56
31
B
2R3RA_6SC
(CDK2)
CMGC
2r3j
I
13
55
30
13
55
30
B
1URWA_I1P
(CDK2)
CMGC
Imidazo[1,2-...
I
12
73
29
12
73
29
B
2EXMA_ZIP
(CDK2)
CMGC
MLS000079197
I
12
22
32
12
22
32
B
1GIIA_1PU
(CDK2)
CMGC
1PU
I
12
60
29
12
60
29
B
1PXMA_CK5
(CDK2)
CMGC
CK5
I
12
36
19
12
36
19
B
2R3MA_SCX
(CDK2)
CMGC
PTK_787
I
11
43
33
11
43
33
B
1PXLA_CK4
(CDK2)
CMGC
4-(2,4-DIMET...
I
11
22
18
11
22
18
B
2B54A_D05
(CDK2)
CMGC
D05
I
11
33
14
11
33
14
B
1V1KA_3FP
(CDK2)
CMGC
AC1NBL9K
I
11
92
39
11
92
39
B
3LFQA_A28
(CDK2)
CMGC
DNC010588
I
10
99
30
10
99
30
B
2VTOA_LZ8
(CDK2)
CMGC
pyrazole dia...
I
10
26
27
10
26
27
B
2C6KA_DT2
(CDK2)
CMGC
2c6k
I
10
42
36
10
42
36
B
2C6LA_DT4
(CDK2)
CMGC
triazolo[1,5...
I
9
40
36
9
40
36
B
1PXOA_CK7
(CDK2)
CMGC
CK7
I
9
23
17
9
23
17
B
1PXNA_CK6
(CDK2)
CMGC
CK6
I
9
22
14
9
22
14
B
1Y91A_CT9
(CDK2)
CMGC
AC1NRAMZ
I
9
40
33
9
40
33
B
1OITA_HDT
(CDK2)
CMGC
4-[(4-IMIDAZ...
I
8
31
24
8
31
24
B
1PXJA_CK2
(CDK2)
CMGC
CK2
I
8
6
14
8
6
14
B
2W06A_FRV
(CDK2)
CMGC
AZD 5438
I
8
59
14
8
59
14
B
2VTAA_LZ1
(CDK2)
CMGC
1H-Indazole
I
7
3
26
7
3
26
B
2C6MA_DT5
(CDK2)
CMGC
2c6m
I
7
40
35
7
40
35
B
2B53A_D23
(CDK2)
CMGC
D23
I
7
38
28
7
38
28
B
1VYZA_N5B
(CDK2)
CMGC
N5B
I
7
43
23
7
43
23
B
3PXZA_JWS
(CDK2)
CMGC
STK626670
I
6
4
16
6
4
16
B
3PXYA_JWS
(CDK2)
CMGC
STK626670
I
6
4
16
6
4
16
B
3IG7A_EFP
(CDK2)
CMGC
3-Phenylacet...
I
6
58
19
6
58
19
B
2VTPA_LZ9
(CDK2)
CMGC
pyrazole dia...
I
6
18
17
6
18
17
B
1KE5A_LS1
(CDK2)
CMGC
LS1
I
5
31
6
5
31
6
B
1KE9A_LS5
(CDK2)
CMGC
LS5
I
5
27
6
5
27
6
B
2VTLA_LZ5
(CDK2)
CMGC
MLS000519301
I
5
18
17
5
18
17
B
2R64A_740
(CDK2)
CMGC
2r64
I
5
27
11
5
27
11
B
3FZ1A_B98
(CDK2)
CMGC
DB07431
I
5
19
5
5
19
5
B
2DS1A_1CD
(CDK2)
CMGC
PI_103
I
5
5
13
5
5
13
B
1YKRA_628
(CDK2)
CMGC
1ykr
I
5
15
13
5
15
13
B
2XNBA_Y8L
(CDK2)
CMGC
CDK Inhibito...
I
5
2
10
5
2
10
B
2XMYA_CDK
(CDK2)
CMGC
CDK Inhibito...
I
5
22
10
5
22
10
B
2R3QA_5SC
(CDK2)
CMGC
2r3j
I
5
13
18
5
13
18
B
2BTRA_U73
(CDK2)
CMGC
BiomolKI_000...
I
3
21
10
3
21
10
B
3LE6A_2BZ
(CDK2)
CMGC
HMS3401P15
I
2
3
6
2
3
6
B
1JSVA_U55
(CDK2)
CMGC
AN-524/12525...
I
2
2
5
2
2
5
B
1KE7A_LS3
(CDK2)
CMGC
LS3
I
2
4
5
2
4
5
B
1KE8A_LS4
(CDK2)
CMGC
LS4
I
2
12
5
2
12
5
B
1Y8YA_CT7
(CDK2)
CMGC
AC1NRAMW
I
2
6
8
2
6
8
B
2DUVA_371
(CDK2)
CMGC
2duv
I
2
17
5
2
17
5
B
2R3PA_3SC
(CDK2)
CMGC
2c68
I
2
7
5
2
7
5
B
2VTIA_LZ3
(CDK2)
CMGC
indazole ami...
I
2
3
5
2
3
5
B
1KE6A_LS2
(CDK2)
CMGC
AC1NRBYB
I
2
2
5
2
2
5
B
2VTJA_LZ4
(CDK2)
CMGC
DB08134
I
2
9
5
2
9
5
B
3IGGA_EFQ
(CDK2)
CMGC
2-(4-methoxy...
I
1
5
5
1
5
5
B
3PY1A_2AN
(CDK2)
CMGC
NHSMVSTXNNRR...
I
1
1
5
1
1
5
B
2VTRA_LZB
(CDK2)
CMGC
DB08139
I
1
2
5
1
2
5
B
3PXZA_2AN
(CDK2)
CMGC
NHSMVSTXNNRR...
I
1
1
5
1
1
5
B
1E1XA_NW1
(CDK2)
CMGC
pyrimidine d...
I
1
7
5
1
7
5
B
1E1VA_CMG
(CDK2)
CMGC
O6-Substitut...
I
1
15
5
1
15
5
B
3PXFA_2AN
(CDK2)
CMGC
NHSMVSTXNNRR...
I
1
1
5
1
1
5
B
1WCCA_CIG
(CDK2)
CMGC
2-AMINO-6-CH...
I
1
1
5
1
1
5
B
1FVTA_106
(CDK2)
CMGC
Oxindole-Bas...
I
1
1
5
1
1
5
B
2VTMA_LZM
(CDK2)
CMGC
pyrazolo[1,5...
I
1
1
5
1
1
5
B
2VTHA_LZ2
(CDK2)
CMGC
5-hydroxynap...
I
1
1
5
1
1
5
B
2UZOA_C62
(CDK2)
CMGC
2uzo
I
1
12
5
1
12
5
B
2UZNA_C96
(CDK2)
CMGC
2uzn
I
1
13
5
1
13
5
B
1PXIA_CK1
(CDK2)
CMGC
aminothiazol...
I
1
1
5
1
1
5
B
1PXKA_CK3
(CDK2)
CMGC
AC1O6ZE4
I
1
1
5
1
1
5
B
1H0WA_207
(CDK2)
CMGC
O6-Substitut...
I
1
16
5
1
16
5
B
1GZ8A_MBP
(CDK2)
CMGC
1-[(2-AMINO-...
I
1
6
5
1
6
5
B
2C5YA_MTW
(CDK2)
CMGC
2c5x
I
1
1
5
1
1
5
B
1W8CA_N69
(CDK2)
CMGC
O6-Cyclohexy...
I
1
11
5
1
11
5
B
2V0DA_C53
(CDK2)
CMGC
MLS000547383
I
1
1
5
1
1
5
C
3
2CLXA_F18
(CDK2)
CMGC
4-(3,5-Diami...
I
3
5
15
C
2CLXA_F18
(CDK2)
CMGC
4-(3,5-Diami...
I
3
5
15
3
5
15
C
3PXQA_2AN
(CDK2)
CMGC
NHSMVSTXNNRR...
I
1
1
5
1
1
5
C
1H0VA_UN4
(CDK2)
CMGC
UN4
I
1
5
5
1
5
5